Exploring Hopes And Fears From Supply Chain Innovations: An Analysis Of Antecedents And Consequences Of Supply Chain Knowledge Exchanges

This dissertation sheds light on severalhopes and fears from supply chain innovation in three distinct papers. Paper one introduces the concept of Process Innovation Propagation as an appropriation technique helping to extract the most returns out of a process innovation by exporting to supply chain partners. Paper two devises and empirically tests knowledge properties that best lead to radical and incremental supply chain innovative capabilities. Lastly, paper three conducts an exploratory study that introduces factors affecting a firm’s optimum supply chain innovation strategy. The dissertation makes a strong argument that supply chain innovation is most prominently governed by power asymmetry that may either help or hurt innovative performance

CrowdCE: A Collaboration Model for Crowdsourcing Software with Computing Elements

Today’s crowd computing models are mainly used for handling independent tasks with simplistic collaboration and coordination through business workflows. However, the software development processes are complex, intellectually and organizationally challenging business models. We present a model for software development that addresses key challenges. It is designed for the crowd in the development of a social application. Our model presents an approach to structurally decompose the overall computing element into atomic machine-based computing elements and human-based computing elements such that the elements can complement each other independently and socially by the crowd. We evaluate our approach by developing a business application through crowd work. We compare our model with the traditional software development models. The primary result was completed well for empowering the crowd

Strategizing niceness in co-opetition: The case of knowledge exchange in supply chain innovation projects

© 2015 Elsevier B.V. All rights reserved. Abstract In this paper, we take a novel approach to address the dilemma of innovation sharing versus protection among supply chain partners. The paper conducts an exploratory study that introduces factors affecting a firm\u27s optimum supply chain innovation strategy. We go beyond the conventional Prisoners\u27 Dilemma, with its limiting assumptions of players\u27 preferences and symmetry, to explore a larger pool of 2 × 2 games that may effectively model the problem. After classifying firm types according to collaboration motive and relative power, we use simulation to explore the effects of firm type, opponent type, and payoff structure on repeated innovation interactions (or, equivalently, long-term relations) and optimality of \u27niceness\u27. Surprisingly, we find that opponent type is essentially irrelevant in long-term innovation interactions, and focal firm type is only conditionally relevant. The paper contributes further by introducing reciprocation of strategy type (nice versus mean), showing that reciprocation is recommended, while identifying and explaining the exceptions to this conclusion

Long-Term Survival in Patients with Cancers: A SEER-based analysis

Objectives: Long-term survival is an important endpoint in management of different malignancies which is rarely assessed due to unfeasibility of follow-up for long duration of time. In this study, we explored real-world data on cancer’s long-term survival using historical records from the Surveillance, Epidemiology, and End Results (SEER) Program. Besides reporting the 5-year relative survival, we analyzed the 10- and 20- year survival rates for different types of cancers. Additionally, survival trends as a function of time, age, and tumor type were reviewed and reported. Methods: We used SEER*Stat (version 8.3.6.1) for data acquisition from the SEER 9 Regs (Nov 2019 Submission) database. Data of patients diagnosed with cancer between 1975 and 2014 were retrieved and included in the analysis. Results: For patients diagnosed with any malignant disease (n = 4,412,024), there was a significant increase in median overall survival over time (p<0.001). The 20-, 10-, and 5-year survival rates were higher in solid tumors compared to hematological malignancies (50.8% vs. 38%, 57% vs. 47.4%, and 62.2% vs. 57.4%, respectively). The highest 20-year relative survival rates were observed in thyroid cancer (95.2%), germ cell and trophoblastic neoplasms (90.3%), melanoma (86.8%), Wilms’ tumor (86.2%), and prostate cancer (83.5%). Conclusions: Long-term follow-up data were suggestive of high 20-year relative survival rates for most tumor types. Relative survival showed an improving trend over time especially in solid tumors. Keywords: Survival; Neoplasms; SEER Program; Prognosis; United States

Effect of Low Level Laser Therapy on Gingival Inflammation in Patients undergoing Fixed Orthodontic Treatment: A Randomized Clinical Trial

AIM: The aim of this study was to compare the effect of low level laser therapy (LLLT) with non-LLLT as an adjunct to mechanical debridement in patients who develop gingival inflammation during fixed orthodontic treatment. MATERIALS AND METHODS: Thirty subjects undergoing comprehensive fixed orthodontic treatment were randomly allocated. Split mouth design was applied for each patient, where the four quadrants were randomly allocated to receive full mouth debridement. The test group (quadrant) received three laser sessions (days 1, 3, and 5) besides debridement while the control group (quadrant) received debridement only. Both bleeding index (BI) and plaque index (PI) were measured after 1 and 3 months, while the total colony forming units (CFU) were measured after 2 and 6 weeks. RESULTS: Clinical assessments (BI and PI) showed a statistically significant decrease at the first follow-up (after 1 month) and a slight increase in the second (after 3 months) that did not reach the base line. While, the total CFU showed a significant decrease in both follow-ups. CONCLUSION: Laser showed superior results in the treatment of gingival inflammation induced by fixed orthodontic appliances other than debridement only

Pandemic (H1N1) 2009 and Hajj Pilgrims Who Received Predeparture Vaccination, Egypt

In Egypt, vaccination against pandemic (H1N1) 2009 virus was required of pilgrims departing for the 2009 Hajj. A survey of 551 pilgrims as they returned to Egypt found 542 (98.1% [weighted]) reported receiving the vaccine; 6 (1.0% [weighted]) were infected with influenza virus A (H3N2) but none with pandemic (H1N1) 2009 virus

Relationship of Oxidant and Antioxidant Markers to Asthma Severity in Egyptian Asthmatic Children

BACKGROUND: Asthma is a chronic airway disease which is characterized by oxidant antioxidant imbalance with the generation of oxidative stress related mediators.AIM: The study aimed to evaluate the role of asymmetric dimethylarginine, and malondialdehyde as oxidant markers and serum paraoxonase activity as an antioxidant marker in asthma, and to determine their relationship to the asthma severity and lung function among asthmatic children in Egypt.PATIENTS AND METHODS: This case control study was conducted on sixty patients with asthma compared with sixty apparently healthy children of matched age and sex.RESULTS: Serum concentrations of oxidant markers as asymmetric dimethylarginine and malondialdehyde were significantly increased in asthmatic patients while anti-oxidant marker as paraoxonase activity was significantly decreased compared to healthy controls (P < 0.05). ANOVA test revealed highly significant elevation of the serum concentrations of oxidant markers while anti-oxidant marker was significantly decreased in severe asthmatic patients (P < 0.001) compared to the patients with moderate and mild asthma respectively. Serum malondialdehyde concentration was a strong predictor of asthma severity by multiple regression analysis (P < 0.05).CONCLUSION: The study revealed an imbalance between oxidative and antioxidant defence systems in asthmatic children. Serum concentration of malondialdehyde was the most predictive biomarker having a significant association with asthma severity

Zoonotic Transmission of Avian Influenza Virus (H5N1), Egypt, 2006–2009

A lower case-fatality rate may have been caused by a less virulent virus clade

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London